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Chemical Structure : Venetoclax
CAS No.: 1257044-40-8
Catalog No.: PC-49764Not For Human Use, Lab Use Only.
Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with Ki value of <0.01 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $98 | In stock | |
| 100 mg | $138 | In stock | |
| 500 mg | $278 | In stock | |
| 1 g | Get quote |
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Venetoclax (ABT-199, GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with Ki value of <0.01 nM.
Venetoclax (ABT-199) displays >4800-fold selectivity for Bcl-2 over Bcl-xL and Bcl-w, and displays no measurable activity at Mcl-1.
Venetoclax (ABT-199) potently induces apoptosis in FL5.12-BCL-2 cells (EC50=261 nM) and reduces tumor burden in chronic lymphocytic leukemia (CLL) primary samples (EC50 =3 nM).
Venetoclax (ABT-199 enhances efficacy of clinically relevant chemotherapy and immunotherapy drugs.
Venetoclax (ABT-199) exhibits binding to SARS-CoV-2 3C-like protease (3CLpro) active site in a virtual screen.
Venetoclax (ABT-199) reverses oxidative phosphorylation in acute myeloid leukemia cells (AML), in vitro and in vivo.
| M.Wt | 868.45 | |
| Formula | C45H50ClN7O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide |
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1. Souers AJ, et al. Nat Med. 2013 Feb;19(2):202-8.
2. Vogler M, et al. Br J Haematol. 2013 Oct;163(1):139-42.
3. Vandenberg CJ, et al. Blood. 2013 Mar 21;121(12):2285-8.
4. Vaillant F, et al. Cancer Cell. 2013 Jul 8;24(1):120-9.
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