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Chemical Structure : Vericiguat
CAS No.: 1350653-20-1
Catalog No.: PC-61605Not For Human Use, Lab Use Only.
Vericiguat (BAY 1021189) is a novel potent, selective, orally available soluble guanylate cyclase (sGC) stimulator (MEC=0.3 uM), stimulating sGC NO-independently and in synergy with NO.
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|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Vericiguat (BAY 1021189) is a novel potent, selective, orally available soluble guanylate cyclase (sGC) stimulator (MEC=0.3 uM), stimulating sGC NO-independently and in synergy with NO.
Vericiguat (BAY 1021189) inhibits the U46619-induced contractions of porcine coronary artery rings with IC50 of 956 nM.
Vericiguat (BAY 1021189) reduces the coronary perfusion pressure in rat heart Langendorff preparations with no effect on heart rate, left ventricular diastolic pressure, and contractility.
| M.Wt | 426.388 | |
| Formula | C19H16F2N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methyl N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate |
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1. Follmann M, et al. J Med Chem. 2017 Jun 22;60(12):5146-5161.
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