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Verosudil

Chemical Structure : Verosudil

CAS No.: 1414854-42-4

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Verosudil (AR-12286, AR12286)

Catalog No.: PC-62715Not For Human Use, Lab Use Only.

Verosudil (AR-12286) is a potent ROCK inhibitor with Ki of 2 nM for both ROCK1 and ROCK2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Verosudil (AR-12286) is a potent ROCK inhibitor with Ki of 2 nM for both ROCK1 and ROCK2.
Verosudil (AR-12286) effectively lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork in animal models.

Physicochemical Properties

M.Wt 327.402
Formula C17H17N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(dimethylamino)-N-(1-oxo- 1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide

References

1. Sturdivant JM, et al. Bioorg Med Chem Lett. 2016 May 15;26(10):2475-80.

2. Kopczynski C, et al. Br J Ophthalmol. 2013 May;97(5):567-72.

3. Williams RD, et al. Am J Ophthalmol. 2011 Nov;152(5):834-41.e1.

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