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Verteporfin

Chemical Structure : Verteporfin

CAS No.: 129497-78-5

Verteporfin (CL 318952, CL318952, BPD-MA)

Catalog No.: PC-36118Not For Human Use, Lab Use Only.

Verteporfin (CL 318952, BPD-MA) is a benzoporphyrin derivative that inhibits Yap via disruption of YAP-TEAD interactions, Verteporfin is a clinically used photosensitizer.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Verteporfin (CL 318952, BPD-MA) is a benzoporphyrin derivative that inhibits Yap via disruption of YAP-TEAD interactions, Verteporfin is a clinically used photosensitizer.
Verteporfin inhibits growth of hepatoma cells without photoactivation through inhibition of YAP-TEAD complex.
Verteporfin inhibited tumor cell proliferation and restored sensitivity to cisplatin in urothelial cell carcinoma (UCC).
Verteporfin blocks tumor growth of uveal melanoma cells containing Gq/11 mutations.

Physicochemical Properties

M.Wt 718.8
Formula C41H42N4O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(4R,4aS)-rel-18-ethenyl-4,4a-dihydro-3,4-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid, monomethyl ester

References

1. Brodowska K, et al. Exp Eye Res. 2014 Jul;124:67-73.

2. Yu FX, et al. Cancer Cell. 2014 Jun 16;25(6):822-30.

3. Perra A, et al. J Hepatol. 2014 Nov;61(5):1088-96.

4. Ciamporcero E, et al. Oncogene. 2016 Mar 24;35(12):1541-53.

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