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Chemical Structure : Verteporfin
CAS No.: 129497-78-5
Catalog No.: PC-36118Not For Human Use, Lab Use Only.
Verteporfin (CL 318952, BPD-MA) is a benzoporphyrin derivative that inhibits Yap via disruption of YAP-TEAD interactions, Verteporfin is a clinically used photosensitizer.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | $648 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Verteporfin (CL 318952, BPD-MA) is a benzoporphyrin derivative that inhibits Yap via disruption of YAP-TEAD interactions, Verteporfin is a clinically used photosensitizer.
Verteporfin inhibits growth of hepatoma cells without photoactivation through inhibition of YAP-TEAD complex.
Verteporfin inhibited tumor cell proliferation and restored sensitivity to cisplatin in urothelial cell carcinoma (UCC).
Verteporfin blocks tumor growth of uveal melanoma cells containing Gq/11 mutations.
| M.Wt | 718.8 | |
| Formula | C41H42N4O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(4R,4aS)-rel-18-ethenyl-4,4a-dihydro-3,4-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid, monomethyl ester |
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1. Brodowska K, et al. Exp Eye Res. 2014 Jul;124:67-73.
2. Yu FX, et al. Cancer Cell. 2014 Jun 16;25(6):822-30.
3. Perra A, et al. J Hepatol. 2014 Nov;61(5):1088-96.
4. Ciamporcero E, et al. Oncogene. 2016 Mar 24;35(12):1541-53.
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