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Chemical Structure : Verubecestat
CAS No.: 1286770-55-5
Catalog No.: PC-45073Not For Human Use, Lab Use Only.
Verubecestat (MK-8931) is a potent, selective, structurally unique BACE inhibitor with Ki of 2.2 nM and 0.38 nM for BACE1 and BACE2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $468 | In stock | |
| 100 mg | Get quote |
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Verubecestat (MK-8931) is a potent, selective, structurally unique BACE inhibitor with Ki of 2.2 nM and 0.38 nM for BACE1 and BACE2, respectively.
Verubecestat (MK-8931) displays high selectivity for BACE1 over other key aspartyl proteases, notably cathepsin D.
Verubecestat (MK-8931) reduces plasma, cerebrospinal fluid (CSF), and brain concentrations of Aβ40, Aβ42, and sAPPβ.
Verubecestat (MK-8931) is well tolerated and produces reductions in Aβ40, Aβ42, and sAPPβ in the CSF of both healthy human subjects and AD patients in clinical evaluation.
| M.Wt | 409.4104 | |
| Formula | C17H17F2N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
2-Pyridinecarboxamide, N-[3-[(5R)-3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro- |
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1. Kennedy ME,, et al. Sci Transl Med. 2016 Nov 2;8(363):363ra150.
2. Scott JD, et al. J Med Chem. 2016 Dec 8;59(23):10435-10450.
3. Villarreal S, et al. J Alzheimers Dis. 2017;59(4):1393-1413.
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