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Verubulin

Chemical Structure : Verubulin

CAS No.: 827031-83-4

Verubulin (MPC6827, MPC-6827)

Catalog No.: PC-25919Not For Human Use, Lab Use Only.

Verubulin (MPC-6827) is a microtubule-destabilizing agent and microtubule formation inhibitor, effectively inhibits the polymerization of tubulin in vitro, inhibits cancer cell lines regardless of the expression levels of the multidrug resistance ABC transporters MDR-1 (Pgp-1), MRP-1, and BCRP-1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Verubulin (MPC-6827) is a microtubule-destabilizing agent and microtubule formation inhibitor, effectively inhibits the polymerization of tubulin in vitro, inhibits cancer cell lines regardless of the expression levels of the multidrug resistance ABC transporters MDR-1 (Pgp-1), MRP-1, and BCRP-1.

Physicochemical Properties

M.Wt 279.34
Formula C17H17N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-Methoxyphenyl)-N,2-dimethylquinazolin-4-amine

References

1. Kasibhatla S, et al. Cancer Res. 2007 Jun 15;67(12):5865-71.

2. Sirisoma N, et al. J Med Chem. 2009 Apr 23;52(8):2341-51.

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