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Chemical Structure : Verucopeptin
Catalog No.: PC-72574Not For Human Use, Lab Use Only.
Verucopeptin (BS-1152) is a cyclodepsipeptide with notable antitumor potency, directly taregts ATP6V1G, a subunit of the vacuolar H+-ATPase (v-ATPase).
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Verucopeptin (BS-1152) is a cyclodepsipeptide with notable antitumor potency, directly taregts ATP6V1G, a subunit of the vacuolar H+-ATPase (v-ATPase).
Verucopeptin exhibited strong inhibition of both v-ATPase activity and mTORC1 signaling, leading to substantial pharmacological efficacy against SGC7901/VCR cell proliferation.
Verucopeptin inhibited tumor growth SGC7901/VCR xenograft model (1 mg/kg) without significant body weight loss or gross signs of toxicity.
Verucopeptin showed excellent antitumor activity against K562R cells with IC50 of 388 nM, showed substantial inhibition of v-ATPase activity at 10 nM in vitro.
| M.Wt | 896.093 | |
| Formula | C43H73N7O13 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Takahashi N, et al. Chem Commun (Camb). 2019 Oct 1;55(79):11956-11959.
2. Wang Y, et al. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8.
3. Sugawara K, et al. J Antibiot (Tokyo). 1993 Jun;46(6):928-35.
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