Catalog No.: PC-72574Not For Human Use, Lab Use Only.
Verucopeptin (BS-1152) is a cyclodepsipeptide with notable antitumor potency, directly taregts ATP6V1G, a subunit of the vacuolar H+-ATPase (v-ATPase).
Verucopeptin (BS-1152) is a cyclodepsipeptide with notable antitumor potency, directly taregts ATP6V1G, a subunit of the vacuolar H+-ATPase (v-ATPase).
Verucopeptin exhibited strong inhibition of both v-ATPase activity and mTORC1 signaling, leading to substantial pharmacological efficacy against SGC7901/VCR cell proliferation.
Verucopeptin inhibited tumor growth SGC7901/VCR xenograft model (1 mg/kg) without significant body weight loss or gross signs of toxicity.
Verucopeptin showed excellent antitumor activity against K562R cells with IC50 of 388 nM, showed substantial inhibition of v-ATPase activity at 10 nM in vitro.
Physicochemical Properties
M.Wt
896.093
Formula
C43H73N7O13
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
L-{Aaa}-G-{Sar}-G-{Sar} Lactone:(Leu1-Sar6)
References
1. Takahashi N, et al. Chem Commun (Camb). 2019 Oct 1;55(79):11956-11959.
2. Wang Y, et al. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8.
3. Sugawara K, et al. J Antibiot (Tokyo). 1993 Jun;46(6):928-35.
