Vestipitant (GW597599) mesylate | NK1 receptor antagonist

Chemical Structure : Vestipitant mesylate

Vestipitant mesylate (GW597599, GW 597588B)

Catalog No.: PC-61579Not For Human Use, Lab Use Only.

Vestipitant (GW597599) mesylate is a potent, selective, orally active NK1 receptor antagonist with pKi of 9.65.

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Biological Activity

Vestipitant (GW597599) mesylate is a potent, selective, orally active NK1 receptor antagonist with pKi of 9.65.
Vestipitant (GW597599) potently blocks Substance P-mediated phosphorylation of ERK.
Vestipitant (GW597599) attenuates fear-induced foot-tapping in gerbils, separation-induced distress-vocalizations in guinea pigs, marble-burying behaviour in mice, and displayes anxiolytic actions in rats.

Physicochemical Properties

M.Wt	587.554
Formula	C24H28F7N3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperazine-1-carboxamide mesylate

References

1. Di Fabio R, et al. J Med Chem. 2009 May 28;52(10):3238-47.

2. Brocco M, et al. Eur Neuropsychopharmacol. 2008 Oct;18(10):729-50.

3. Ratti E, et al. Sleep. 2013 Dec 1;36(12):1823-30.

4. Poma SZ, et al. J Psychopharmacol. 2014 May;28(5):491-7.

Vestipitant mesylate (GW597599, GW 597588B)

Biological Activity

Physicochemical Properties

References

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