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Chemical Structure : Vilazodone
CAS No.: 163521-12-8
Catalog No.: PC-23306Not For Human Use, Lab Use Only.
Vilazodone (EMD68843, SB659746A) is a potent, dual 5-HT1A agonist and serotonin reuptake inhibitor (SSRI) with IC50 of 0.2 nM at the human 5-HT1A receptor and 0.5 nM for the SERT.
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|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
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Vilazodone (EMD68843, SB659746A) is a potent, dual 5-HT1A agonist and serotonin reuptake inhibitor (SSRI) with IC50 of 0.2 nM at the human 5-HT1A receptor and 0.5 nM for the SERT.
Vilazodone (EMD 68843; SB 659746A) binds to the high agonist affinity state of human 5-HT1A receptors, and displays high affinity (pKi≥9.3) for human recombinant and rat, guinea pig, mouse, and marmoset native tissue 5-HT1A receptors.
Vilazodone (EMD 68843; SB 659746A) is a potent 5‐HT reuptake inhibitor in rat and guinea pig cortex, inhibits [3H]5‐HT uptake with a pIC50 of 8.8 in LLCPK cells expressing human SERT.
Vilazodone (3 mg/kg ; i.p,; single dose) produces increases in extracellular levels of 5‐HT in both the frontal cortex (FC) and ventral hippocampus (vHipp) of rats.
| M.Wt | 441.54 | |
| Formula | C26H27N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide |
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1. Hughes ZA, et al. Eur J Pharmacol. 2005 Mar 7;510(1-2):49-57.
2. Heinrich T, et al. J Med Chem. 2004 Sep 9;47(19):4684-92.
3. Heinrich T, et al. Bioorg Med Chem. 2004 Sep 15;12(18):4843-52.
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