Catalog No.: PC-23306Not For Human Use, Lab Use Only.
Vilazodone (EMD68843, SB659746A) is a potent, dual 5-HT1A agonist and serotonin reuptake inhibitor (SSRI) with IC50 of 0.2 nM at the human 5-HT1A receptor and 0.5 nM for the SERT.
Vilazodone (EMD68843, SB659746A) is a potent, dual 5-HT1A agonist and serotonin reuptake inhibitor (SSRI) with IC50 of 0.2 nM at the human 5-HT1A receptor and 0.5 nM for the SERT. Vilazodone (EMD 68843; SB 659746A) binds to the high agonist affinity state of human 5-HT1A receptors, and displays high affinity (pKi≥9.3) for human recombinant and rat, guinea pig, mouse, and marmoset native tissue 5-HT1A receptors. Vilazodone (EMD 68843; SB 659746A) is a potent 5‐HT reuptake inhibitor in rat and guinea pig cortex, inhibits [3H]5‐HT uptake with a pIC50 of 8.8 in LLCPK cells expressing human SERT. Vilazodone (3 mg/kg ; i.p,; single dose) produces increases in extracellular levels of 5‐HT in both the frontal cortex (FC) and ventral hippocampus (vHipp) of rats.
