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Chemical Structure : Vinorelbine
CAS No.: 71486-22-1
Catalog No.: PC-42866Not For Human Use, Lab Use Only.
Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM.
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|---|---|---|---|
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM.
Vinorelbine induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.
| M.Wt | 778.9323 | |
| Formula | C45H54N4O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)- |
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1. Rahmani R, et al. Cancer Chemother Pharmacol. 1986;16(3):223-8.
2. Ngan VK, et al. Mol Pharmacol. 2001 Jul;60(1):225-32.
3. Monnet I, et al. Eur J Cancer. 1991;27(12):1716-7.
4. Rahmani R, et al. Cancer Res. 1984 Dec;44(12 Pt 1):5609-13.
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