Vinorelbine | Tubulin inhibitor | Probechem Biochemicals

Chemical Structure : Vinorelbine

CAS No.: 71486-22-1

Vinorelbine (KW-2307)

Catalog No.: PC-42866Not For Human Use, Lab Use Only.

Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM.

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Biological Activity

Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM.
Vinorelbine induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.

Physicochemical Properties

M.Wt	778.9323
Formula	C45H54N4O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-

References

1. Rahmani R, et al. Cancer Chemother Pharmacol. 1986;16(3):223-8.

2. Ngan VK, et al. Mol Pharmacol. 2001 Jul;60(1):225-32.

3. Monnet I, et al. Eur J Cancer. 1991;27(12):1716-7.

4. Rahmani R, et al. Cancer Res. 1984 Dec;44(12 Pt 1):5609-13.

Vinorelbine (KW-2307)

Biological Activity

Physicochemical Properties

References

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