Vinorelbine ditartrate | Tubulin inhibitor

Chemical Structure : Vinorelbine ditartrate

CAS No.: 125317-39-7

Vinorelbine ditartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate)

Catalog No.: PC-42867Not For Human Use, Lab Use Only.

Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM.

Packing	Price	Stock
25 mg	$98	In stock
50 mg	$148	In stock
100 mg	$238	In stock
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Biological Activity

Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM.
Vinorelbine induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.

Physicochemical Properties

M.Wt	1079.106
Formula	C53H66N4O20
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 46 mg/mL
Chemical Name/SMILES	Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-, (2R,3R)-2,3-dih

References

1. Rahmani R, et al. Cancer Chemother Pharmacol. 1986;16(3):223-8.

2. Ngan VK, et al. Mol Pharmacol. 2001 Jul;60(1):225-32.

3. Monnet I, et al. Eur J Cancer. 1991;27(12):1716-7.

4. Rahmani R, et al. Cancer Res. 1984 Dec;44(12 Pt 1):5609-13.

Vinorelbine ditartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate)

Biological Activity

Physicochemical Properties

References

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