You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-Vinpocetine
Vinpocetine

Chemical Structure : Vinpocetine

CAS No.: 42971-09-5

Vinpocetine (Ethyl apovincaminate)

Catalog No.: PC-43473Not For Human Use, Lab Use Only.

Vinpocetine (Ethyl apovincaminate) is a synthetic derivative of the vinca alkaloid vincamine, selectively inhibits PDE1 in isolated rabbit aorta with IC50 of 21 uM.

Packing Price Stock Quantity
100 mg $78 In stock
200 mg $118 In stock
1 g $11 In stock

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Vinpocetine (Ethyl apovincaminate) is a synthetic derivative of the vinca alkaloid vincamine, selectively inhibits PDE1 in isolated rabbit aorta with IC50 of 21 uM.
Vinpocetine inhibits IKK preventing IκB degradation and the following translocation of NF-κB to the cell nucleus.
Vinpocetine potently inhibits TNF-alpha- or LPS-induced up-regulation of proinflammatory mediators, including TNF-alpha, IL-1beta, and macrophage inflammatory protein-2, and decreases interstitial infiltration of polymorphonuclear leukocytes in mouse model of lung inflammation.
Vinpocetine demonstrates cerebral blood-flow enhancing and neuroprotective effects in vivo.

Physicochemical Properties

M.Wt 350.45
Formula C22H26N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: < 1 mg/mL

Chemical Name/SMILES

Eburnamenine-14-carboxylic acid, ethyl ester, (3α,16α)-

References

1. Souness JE, et al. Br J Pharmacol. 1989 Nov;98(3):725-34.

2. Tomkinson A, et al. Br J Pharmacol. 1996 Aug;118(8):2131-9.

3. Loughney K, et al. J Biol Chem. 1996 Jan 12;271(2):796-806.

4. Jeon KI, et al. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9795-800.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: