Vixarelimab | Anti-OSMRβ mAb | Probechem Biochemicals

Chemical Structure : Vixarelimab

Vixarelimab (KPL 716)

Catalog No.: PC-38872Not For Human Use, Lab Use Only.

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Biological Activity

Vixarelimab (KPL-716) is a fully-human monoclonal antibody that targets oncostatin M receptor beta (OSMRβ), which mediates signaling of interleukin-31 (IL-31) and oncostatin M (OSM), two key cytokines implicated in pruritus, inflammation and fibrosis.
Vixarelimab (KPL-716) significantly attenuated MCP-1 response to OSM and OSM + IL-4 in human epidermal keratinocytes and human dermal fibroblasts, but not anti-IL-31Rα.

Isotype: IgG4-G1-lambda2.

Anti-[human OSMR (oncostatin M receptor, OSMRB, OSMRbeta)], human monoclonal antibody.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES

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Vixarelimab (KPL 716)

Biological Activity

Physicochemical Properties

References

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