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Chemical Structure : Vixarelimab
Catalog No.: PC-38872Not For Human Use, Lab Use Only.
Vixarelimab (KPL-716) is a fully-human monoclonal antibody that targets oncostatin M receptor beta (OSMRβ), which mediates signaling of interleukin-31 (IL-31) and oncostatin M (OSM), two key cytokines implicated in pruritus, inflammation and fibrosis.
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Vixarelimab (KPL-716) is a fully-human monoclonal antibody that targets oncostatin M receptor beta (OSMRβ), which mediates signaling of interleukin-31 (IL-31) and oncostatin M (OSM), two key cytokines implicated in pruritus, inflammation and fibrosis.
Vixarelimab (KPL-716) significantly attenuated MCP-1 response to OSM and OSM + IL-4 in human epidermal keratinocytes and human dermal fibroblasts, but not anti-IL-31Rα.
Isotype: IgG4-G1-lambda2.
Anti-[human OSMR (oncostatin M receptor, OSMRB, OSMRbeta)], human monoclonal antibody.
| M.Wt | ||
| Formula | ||
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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