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Voreloxin

Chemical Structure : Voreloxin

CAS No.: 175414-77-4

Voreloxin (SNS-595, Vosaroxin, AG 7352)

Catalog No.: PC-42643Not For Human Use, Lab Use Only.

Voreloxin (SNS-595;Vosaroxin;AG 7352) is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II, exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Voreloxin (SNS-595; Vosaroxin; AG 7352) is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II, exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively.

Physicochemical Properties

M.Wt 401.4396
Formula C18H19N5O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-

References

1. Scatena CD, et al. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8.

2. Hoch U, et al. Cancer Chemother Pharmacol. 2009 Jun;64(1):53-65.

3. Walsby EJ, et al. Haematologica. 2011 Mar;96(3):393-9.

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