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Vorinostat

Chemical Structure : Vorinostat

CAS No.: 149647-78-9

Vorinostat (SAHA;Suberoylanilide hydroxamic acid;MK-0683)

Catalog No.: PC-42465Not For Human Use, Lab Use Only.

Vorinostat (SAHA) is a potent HDAC inhibitor, inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively.

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Biological Activity

Vorinostat (SAHA) is a potent HDAC inhibitor, inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively.
Vorinostat (SAHA) inhibits cell growth, induces terminal differentiation and prevents the formation of tumours in mice models.

Physicochemical Properties

M.Wt 264.3202
Formula C14H20N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 100 mg/mL

Chemical Name/SMILES

Octanediamide, N1-hydroxy-N8-phenyl-

References

1. Richon VM, et al. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7.

2. Finnin MS, et al. Nature. 1999 Sep 9;401(6749):188-93.

3. Vrana JA, et al. Oncogene. 1999 Nov 25;18(50):7016-25.

4. Richon VM, et al. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10014-9.

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