Votoplam (PTC518) is a small molecule HTT gene modulator and splicing modifier, selectively lowers huntingtin mRNA and protein.
Votoplam (PTC518) promotes the inclusion of a novel pseudoexon containing a premature termination codon, thus triggering HTT mRNA degradation and subsequent reduction in HTT protein levels.
Votoplam (PTC518) demonstrated a dose-dependent lowering of HTT mRNA and protein to the targeted 30-50% reduction in a Phase 1 healthy volunteer study of PTC518 for Huntington's disease.
