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Voxilaprevir

Chemical Structure : Voxilaprevir

CAS No.: 1535212-07-7

Voxilaprevir (GS-9857, GS9857)

Catalog No.: PC-61440Not For Human Use, Lab Use Only.

Voxilaprevir (GS-9857) is a potent HCV NS3/4A protease inhibitor that is used in combination with sofosbuvir and velpatasvir for treatment of HCV infection.

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Biological Activity

Voxilaprevir (GS-9857) is a potent HCV NS3/4A protease inhibitor that is used in combination with sofosbuvir and velpatasvir for treatment of HCV infection.

Physicochemical Properties

M.Wt 868.94
Formula C40H52F4N6O9S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(33R,34S,35S,91R,92R,5S)-5-(tert-butyl)-N-((1R,2R)-2-(difluoromethyl)-1-(((1-methylcyclopropyl)sulfonyl)carbamoyl)cyclopropyl)-34-ethyl-14,14-difluoro-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxamide

References

1. Bourlière M, et al. N Engl J Med. 2017 Jun 1;376(22):2134-2146.

2. Gane EJ, et al. Gastroenterology. 2016 Nov;151(5):902-909.

3. Lawitz E, et al. Gastroenterology. 2016 Nov;151(5):893-901.e1.

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