Voxtalisib |CAS:934493-76-2 Probechem Biochemicals

Chemical Structure : Voxtalisib

CAS No.: 934493-76-2

Voxtalisib (XL765;SAR245409;SAR-245409;XL 765;XL-765)

Catalog No.: PC-44791Not For Human Use, Lab Use Only.

Voxtalisib (XL765, SAR245409) is a potent, highly selective ATP-competitive inhibitor of class I PI3Ks with IC50s of 39/110/43/9 nM for p110α/p110β/p110δ/p120γ.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
100 mg		Get quote

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Biological Activity

Voxtalisib (XL765, SAR245409) is a potent, highly selective ATP-competitive inhibitor of class I PI3Ks with IC50s of 39/110/43/9 nM for p110α/p110β/p110δ/p120γ.
Voxtalisib (XL765, SAR245409) also inhibits mTORC1/mTORC2/DNA-PK (IC50=160/910/150 nM) and shows weak inhibitory activity toward VPS34 (IC50=9.1 uM).
Voxtalisib (XL765, SAR245409) inhibits phosphorylation of AKT, p70S6K, and S6 phosphorylation in multiple tumor cell lines.
Voxtalisib (XL765, SAR245409) is orally bioactive in mouse xenograft models.

Physicochemical Properties

M.Wt	270.2899
Formula	C13H14N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 16 mg/mL
Chemical Name/SMILES	Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)-

References

1. Yu P, et al. Mol Cancer Ther. 2014 May;13(5):1078-91.

2. Papadopoulos KP, et al. Clin Cancer Res. 2014 May 1;20(9):2445-56.

3. Thijssen R, et al. Leukemia. 2016 Feb;30(2):337-45.

Voxtalisib (XL765;SAR245409;SAR-245409;XL 765;XL-765)

Biological Activity

Physicochemical Properties

References

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