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Chemical Structure : Vps34-IN-1
CAS No.: 1383716-33-3
Catalog No.: PC-43214Not For Human Use, Lab Use Only.
Vps34-IN-1 is a potent, selective inhibitor of class III PI3K Vps34 with IC50 of 25 nM, does not inhibit class I and II PI3Ks, as well as a broad panel of protein kinases or lipid kinases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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Vps34-IN-1 is a potent, selective inhibitor of class III PI3K Vps34 with IC50 of 25 nM, does not inhibit class I and II PI3Ks, as well as a broad panel of protein kinases or lipid kinases.
Vps34-IN-1 rapidly reduces endosomal PtdIns(3)P levels, induces a rapid ~50-60% loss of SGK3 phosphorylation in cells, does not inhibit activity of the SGK2 isoform.
Vps34-IN1 is a useful probe to delineate physiological roles of the Vps34.
| M.Wt | 425.9146 | |
| Formula | C21H24ClN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
2-Propanol, 1-[[2-[(2-chloro-4-pyridinyl)amino]-4'-(cyclopropylmethyl)[4,5'-bipyrimidin]-2'-yl]amino]-2-methyl- |
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1. Bago R, et al. Biochem J. 2014 Nov 1;463(3):413-27.
2. Valet C, et al. Blood. 2017 Nov 2;130(18):2032-2042.
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