Catalog No.: PC-61541Not For Human Use, Lab Use Only.
W-212393 (MT-7716 free base) is a highly potent, brain penetrant ORL1 receptor (NOP receptor) agonist with Ki of 0.76 and 0.50 nM for rat and human ORL1 receptors, respectively.
W-212393 (MT-7716 free base) is a highly potent, brain penetrant ORL1 receptor (NOP receptor) agonist with Ki of 0.76 and 0.50 nM for rat and human ORL1 receptors, respectively.
W-212393 displays a relative selectivity over μ receptor and serotonin transporter.
W-212393 significantly suppresses the activity of spontaneously firing rat suprachiasmatic nucleus neurons at 100 nM.
W-212393 induces a significant phase advance at circadian time 6 (CT6) and CT9, but not at other CTs, represents an interesting agent for the study of circadian rhythms.
MT-7716 dose-dependently decreases GABAergic transmission and effectively blocks the ethanol-induced increase in GABA release at these synapses.
