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W146

Chemical Structure : W146

CAS No.: 909725-61-7

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W146 (S1P1 antagonist W146)

Catalog No.: PC-63010Not For Human Use, Lab Use Only.

W146 is a potent, selective S1P1 antagonist with Ki of 18 nM, displays no effect at S1P2, S1P3 or S1P5, enhances capillary leakage and restores lymphocyte egress in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

W146 is a potent, selective S1P1 antagonist with Ki of 18 nM, displays no effect at S1P2, S1P3 or S1P5, enhances capillary leakage and restores lymphocyte egress in vivo.

Physicochemical Properties

M.Wt 342.376
Formula C16H27N2O4P
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

[(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid

References

1. Sanna MG, et al. Nat Chem Biol. 2006 Aug;2(8):434-41.

2. Gonzalez-Cabrera PJ, et al. Mol Pharmacol. 2008 Nov;74(5):1308-18.

3. Tarrasón G, et al. Int Immunopharmacol. 2011 Nov;11(11):1773-9.

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