W2014-S

Chemical Structure : W2014-S

Catalog No.: PC-20627Not For Human Use, Lab Use Only.

W2014-S is a small molecule STAT3 inhibitor with binding Kd of 3.64 uM, disrupts STAT3 dimerization and selectively inhibits STAT3 signaling.

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

W2014-S is a small molecule STAT3 inhibitor with binding Kd of 3.64 uM, disrupts STAT3 dimerization and selectively inhibits STAT3 signaling.
W2014-S inhibitsthe cell proliferation dose-dependently with IC50 values of 0.89 μM and 2.42 μM in A549 cell line, and of 2.36 μM and 2.66 μM in PC-9 cell line, respectively.
W2014-S significantly suppressed the colony formation at as low as 0.3 μM concentration in A549 and PC-9 cell lines in colony survival assay.
W2014-S (i.p. 5 or 15 mg/kg/day) inhibited the growth of human lung cancer cell xenografts and PDX models in vivo.

Physicochemical Properties

M.Wt	496.61
Formula	C30H32N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N1CC=C(C2=CC=C3C(N=C(C4=CC=C(O[C@H](C5=CC=CC=C5)C)C=C4)N3)=N2)CC1)OC(C)(C)C

References

1. Qiyao Zheng, et al. Theranostics. 2021 Jan 1;11(2):824-840.

W2014-S

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.