W2014-S is a small molecule STAT3 inhibitor with binding Kd of 3.64 uM, disrupts STAT3 dimerization and selectively inhibits STAT3 signaling.
W2014-S inhibitsthe cell proliferation dose-dependently with IC50 values of 0.89 μM and 2.42 μM in A549 cell line, and of 2.36 μM and 2.66 μM in PC-9 cell line, respectively.
W2014-S significantly suppressed the colony formation at as low as 0.3 μM concentration in A549 and PC-9 cell lines in colony survival assay.
W2014-S (i.p. 5 or 15 mg/kg/day) inhibited the growth of human lung cancer cell xenografts and PDX models in vivo.
