Chemical Structure : W2A-28
CAS No.:
2803203-72-5
W2A-28
Catalog No.: PC-26795Not For Human Use, Lab Use Only.
W2A-28 is a dual modulator of class I HDACs and Wnt/β-catenin signaling, inhibits HDAC1, 2 and 3 with IC50 of 0.51 μM, 0.68 μM and 0.22 μM, respectively, activates Wnt/β-catenin signaling with EC50 of 1.61 μM in Wnt-3A-expressing HEK293 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
W2A-28 is a dual modulator of class I HDACs and Wnt/β-catenin signaling, inhibits HDAC1, 2 and 3 with IC50 of 0.51 μM, 0.68 μM and 0.22 μM, respectively, activates Wnt/β-catenin signaling with EC50 of 1.61 μM in Wnt-3A-expressing HEK293 cells.
W2A-28 has no inhibitory effects on other HDACs.
Upregulation of LRP6 protein is associated with W2A-28-mediated activation of Wnt/β-catenin signaling.
W2A-28 induces histone acetylation and activates Wnt/β-catenin signaling in AD patient-specific iPSC-derived cerebral organoids.
W2A-28 significantly inhibits tau phosphorylation in AD patient-specific iPSC-derived cerebral organoids.
Physicochemical Properties
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M.Wt
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270.29
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Formula
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C14H14N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-acetamido-N-(2-aminophenyl)picolinamide
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References
1. Lu W, et al. bioRxiv [Preprint]. 2026 May 5:2026.04.30.721954.
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