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WAY-196025

Chemical Structure : WAY-196025

CAS No.: 540523-42-0

WAY-196025 (WAY196025)

Catalog No.: PC-61842Not For Human Use, Lab Use Only.

WAY-196025 is a potent, selective, and orally active inhibitor of cPLA2α with IC50 of 12 nM for LTB4 inhibition.

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    Biological Activity

    WAY-196025 is a potent, selective, and orally active inhibitor of cPLA2α with IC50 of 12 nM for LTB4 inhibition.
    WAY-196025 shows efficacy in multiple acute and chronic prostaglandin and leukotriene dependent in vivo models.

    Physicochemical Properties

    M.Wt 746.14
    Formula C40H35Cl3N2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-(3-(1-benzhydryl-5-chloro-2-(2-(((3,4-dichlorophenyl)methyl)sulfonamido)ethyl)-1H-indol-3-yl)propyl)benzoic acid

    References

    1. McKew JC, et al. J Med Chem. 2008 Jun 26;51(12):3388-413.

    2. Whalen KA, et al. Clin Exp Allergy. 2008 Oct;38(10):1590-605.

    3. Marusic S, et al. J Neuroimmunol. 2008 Nov 15;204(1-2):29-37.

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