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WAY-262611

Chemical Structure : WAY-262611

CAS No.: 1123231-07-1

WAY-262611 (WAY262611, WAY 262611)

Catalog No.: PC-42795Not For Human Use, Lab Use Only.

WAY-262611 (WAY262611) is a potent, orally active and Wnt/β-catenin pathway agonist with EC50 of 0.63 nM, via inhibition of dickkopf-1 (DKK-1).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

WAY-262611 (WAY262611) is a potent, orally active and Wnt/β-catenin pathway agonist with EC50 of 0.63 nM, via inhibition of dickkopf-1 (DKK-1).
WAY-262611 increases bone formation rate in ovariectomized rats.
WAY-262611 inhibits cell migration of fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis.

Physicochemical Properties

M.Wt 318.4155
Formula C20H22N4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 42 mg/mL

Chemical Name/SMILES

4-Piperidinemethanamine, 1-[4-(2-naphthalenyl)-2-pyrimidinyl]-

References

1. Pelletier JC, et al. J Med Chem. 2009 Nov 26;52(22):6962-5.

2. Enochson L, et al. Osteoarthritis Cartilage. 2014 Apr;22(4):566-77.

3. Choe JY, et al. Rheumatology (Oxford). 2016 May;55(5):928-38.

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