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WAY-267464

Chemical Structure : WAY-267464

CAS No.: 1432043-31-6

WAY-267464 (WAY267464)

Catalog No.: PC-35701Not For Human Use, Lab Use Only.

WAY-267464 (WAY267464) is a potent, selective, non-peptide oxytocin receptor agonist with Ki of 58.4 nM, >100-fold selectivity over V1a, V2, V1b receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    WAY-267464 (WAY267464) is a potent, selective, non-peptide oxytocin receptor agonist with Ki of 58.4 nM, >100-fold selectivity over V1a, V2, V1b receptors.
    WAY-267464 exhibits an anxiolytic-like profile similar to oxytocin (OT), also significantly reverses disruption in prepulse inhibition of the acoustic startle reflex induced by either MK-801 or amphetamine in vivo.

    Physicochemical Properties

    M.Wt 654.593
    Formula C32H37Cl2N7O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-(3,5-Dihydroxy-benzyl)-piperazine-1-carboxylic acid 2-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide dihydrochloride

    References

    1. Ring RH, et al. Neuropharmacology. 2010 Jan;58(1):69-77.

    2. Hicks C, et al. J Neuroendocrinol. 2012 Jul;24(7):1012-29.

    3. Hicks C, et al. Br J Pharmacol. 2014 Jun;171(11):2868-87.

    4. Hicks C, et al. Psychopharmacology (Berl). 2015 Aug;232(15):2659-67.

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