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WAY-362692

Chemical Structure : WAY-362692

CAS No.: 915763-27-8

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WAY-362692 (WAY362692)

Catalog No.: PC-63016Not For Human Use, Lab Use Only.

WAY-362692 is a small molecule inhibitor of the secreted frizzled-related protein sFRP-1 with IC50 of 20 nM in FP binding assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    WAY-362692 is a small molecule inhibitor of the secreted frizzled-related protein sFRP-1 with IC50 of 20 nM in FP binding assay.
    WAY-362692 exhibits Wnt signaling inhibition in U2-OS cell lines with EC50 of 30 nM.
    WAY-362692 increases total bone area (75%) relative to the vehicle control in an ex vivo mouse calvaria model for bone formation.

    Physicochemical Properties

    M.Wt 644.725
    Formula C28H35F3N4O6S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2S)-N-(tert-Butyl)-2-{[4-({[5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]carbonyl}pyrrolidine-1-carboxamid

    References

    1. Moore WJ, et al. J Med Chem. 2009 Jan 8;52(1):105-16.

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