WCDD301 | EphA4 agonist | Probechem Biochemicals

Chemical Structure : WCDD301

WCDD301 (WCDD 301)

Catalog No.: PC-21784Not For Human Use, Lab Use Only.

WCDD301 is a high-affinity, orally available agonist of EphA4 receptor, competitively binds to the EphA4 receptor Ki of 0.13 uM, functions as an EphA4 agonist and competes with the natural ligand, Ephrin-A5.

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Biological Activity

WCDD301 is a high-affinity, orally available agonist of EphA4 receptor, competitively binds to the EphA4 receptor Ki of 0.13 uM, functions as an EphA4 agonist and competes with the natural ligand, Ephrin-A5.

WCDD301 suppresses glucagon secretion in murine α cells by binding to EphA4 receptor.

WCDD301 suppresses glucagon secretion from human α cells in both healthy and type 1 diabetic participants.

WCDD301 enhances intracellular F-actin and EphA4 intensities in both human and mouse dispersed islet cells.

WCDD301 recovers mononuclear cell infiltrate and restores F-actin and EphA4 intensities in islets of NOD diabetic mice.

WCDD301 normalizes blood glucose levels in diabetic mouse models that is accompanied by improvement in glucose tolerance.

WCDD301 does not alter plasma levels of GLP-1, glutamine, and somatostatin and normalizes hyperglucosuria, polyphagia, and weight loss in diabetic NOD mice.

Physicochemical Properties

M.Wt	247.25
Formula	C10H17NO6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(acetoxymethyl)-2-aminopropane-1,3-diyl diacetate

References

1. Farzad Asadi, et al. JCI Insight. 2024 Jan 23;9(2):e172626.

WCDD301 (WCDD 301)

Biological Activity

Physicochemical Properties

References

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