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Chemical Structure : WEE1-CK1α molecular glue degrader 1
Catalog No.: PC-23399Not For Human Use, Lab Use Only.
WEE1-CK1α molecular glue degrader 1 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.1 nM and 3.4 nM in MOLT-4 cells respectively.
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WEE1-CK1α molecular glue degrader 1 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.1 nM and 3.4 nM in MOLT-4 cells respectively.
WEE1-CK1α molecular glue degrader 1 has a significant antiproliferative effect (EC50 = 12 nM, MOLT-4 cells).
| M.Wt | 431.50 | |
| Formula | C24H25N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Razumkov H, et al. J Am Chem Soc. 2024 Nov 5. doi: 10.1021/jacs.4c06127.
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