WEE1-CK1α molecular glue degrader 10

Chemical Structure : WEE1-CK1α molecular glue degrader 10

Catalog No.: PC-23400Not For Human Use, Lab Use Only.

WEE1-CK1α molecular glue degrader 10 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.6 nM and 1.5 nM in MOLT-4 cells respectively.

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Biological Activity

WEE1-CK1α molecular glue degrader 10 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.6 nM and 1.5 nM in MOLT-4 cells respectively.
WEE1-CK1α molecular glue degrader 10 demonstrates potent degradation of the WT WEE1 KD (DC50 = 0.35 nM, Dmax = 88%), while the G322A mutation showed 50-fold rescue (DC50 = 17 nM, Dmax = 54%).

Physicochemical Properties

M.Wt	509.61
Formula	C30H31N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(3-(((3s,5s,7s)-adamantan-1-yl)amino)imidazo[1,2-a]pyridin-2-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

References

1. Razumkov H, et al. J Am Chem Soc. 2024 Nov 5. doi: 10.1021/jacs.4c06127.

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