WEE1-CK1α molecular glue degrader 1

Chemical Structure : WEE1-CK1α molecular glue degrader 1

Catalog No.: PC-23399Not For Human Use, Lab Use Only.

WEE1-CK1α molecular glue degrader 1 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.1 nM and 3.4 nM in MOLT-4 cells respectively.

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Biological Activity

WEE1-CK1α molecular glue degrader 1 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.1 nM and 3.4 nM in MOLT-4 cells respectively.
WEE1-CK1α molecular glue degrader 1 has a significant antiproliferative effect (EC50 = 12 nM, MOLT-4 cells).

Physicochemical Properties

M.Wt	431.50
Formula	C24H25N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(3-(tert-butylamino)imidazo[1,2-a]pyridin-2-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

References

1. Razumkov H, et al. J Am Chem Soc. 2024 Nov 5. doi: 10.1021/jacs.4c06127.

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