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Chemical Structure : WEE1-CK1α molecular glue degrader 10
Catalog No.: PC-23400Not For Human Use, Lab Use Only.
WEE1-CK1α molecular glue degrader 10 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.6 nM and 1.5 nM in MOLT-4 cells respectively.
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WEE1-CK1α molecular glue degrader 10 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.6 nM and 1.5 nM in MOLT-4 cells respectively.
WEE1-CK1α molecular glue degrader 10 demonstrates potent degradation of the WT WEE1 KD (DC50 = 0.35 nM, Dmax = 88%), while the G322A mutation showed 50-fold rescue (DC50 = 17 nM, Dmax = 54%).
| M.Wt | 509.61 | |
| Formula | C30H31N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Razumkov H, et al. J Am Chem Soc. 2024 Nov 5. doi: 10.1021/jacs.4c06127.
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