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WEE1Hu inhibitor 1

Chemical Structure : WEE1Hu inhibitor 1

CAS No.: 2211167-11-0

WEE1Hu inhibitor 1 (Wee1A inhibitor 1)

Catalog No.: PC-35251Not For Human Use, Lab Use Only.

WEE1Hu inhibitor is a novel potent inhibitor of WEE1Hu kinase (also known as Wee1A) with IC50 of 68 nM against recombined WEE1Hu in ELISA assays.

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    Biological Activity

    WEE1Hu inhibitor 1 is a novel potent inhibitor of WEE1Hu kinase (also known as Wee1A) with IC50 of 68 nM against recombined WEE1Hu in ELISA assays.
    WEE1Hu inhibitor 1 inhibits lung cancer cell Hep-3B and Huh-7 cell proliferation with IC50 of <1 uM and 10-100 uM, respectively.

    Physicochemical Properties

    M.Wt 461.311
    Formula C18H20IN7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-(1H-imidazol-1-yl)-5-iodo-N-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine

    References

    1. US Patent WO 2018056621.

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