WEE1 degrader 2

Chemical Structure : WEE1 degrader 2

Catalog No.: PC-22391Not For Human Use, Lab Use Only.

WEE1 degrader 2 is a potent, selective CRBN-dependent WEE1 molecular glue degrader with DC50 of 140 nM and Emax of 85%, does not degrade CK1α.

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Biological Activity

WEE1 degrader 2 is a potent, selective CRBN-dependent WEE1 molecular glue degrader with DC50 of 140 nM and Emax of 85%, does not degrade CK1α.

M.Wt	543.62
Formula	C30H33N5O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-dioxopiperidin-3-yl)-5-(5-methyl-2-((2,4,4-trimethylpentan-2-yl)amino)imidazo[1,2-a]pyridine-3-carbonyl)isoindoline-1,3-dione

1. Razumkov H, et al. bioRxiv [Preprint]. 2024 May 5:2024.05.04.592550.