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Chemical Structure : WEHI-345
CAS No.: 1354825-58-3
Catalog No.: PC-45564Not For Human Use, Lab Use Only.
WEHI-345 is a potent and selective RIPK2 inhibitor with IC50/Kd of 130/46 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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WEHI-345 is a potent and selective RIPK2 inhibitor with IC50/Kd of 130/46 nM.
WEHI-345 displays negligible activity (>10 uM) against RIPK1, RIPK4 and RIPK5.
WEHI-345 delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement.
WEHI-345 prevents cytokine production in vitro and in vivo and ameliorates experimental autoimmune encephalomyelitis in mice.
| M.Wt | 401.4643 | |
| Formula | C22H23N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
4-Pyridinecarboxamide, N-[2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]- |
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1. Nachbur U, et al. Nat Commun. 2015 Mar 17;6:6442.
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