Chemical Structure : WEHI-3773
CAS No.:
WEHI-3773
Catalog No.: PC-24290Not For Human Use, Lab Use Only.
WEHI-3773 is a small molecule inhibitor of interaction between VDAC2 and BAX, inhibits apoptosis mediated by BAX by blocking VDAC2-mediated BAX recruitment to mitochondria.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
WEHI-3773 is a small molecule inhibitor of interaction between VDAC2 and BAX, inhibits apoptosis mediated by BAX by blocking VDAC2-mediated BAX recruitment to mitochondria.
WEHI-3773 inhibits BAX activation and translocation to limit MOMP and protect cells.
WEHI-3773 inhibits VDAC2-mediated BAX recruitment to mitochondria.
WEHI-3773 primes BAK activation by destabilizing its interaction with VDAC2.
WEHI-3773 targets VDAC2 to modulate BAK and BAX.
WEHI-3773 overcomes venetoclax resistance in leukemic cells.
Physicochemical Properties
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M.Wt
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618.69
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Formula
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C30H22N10O2S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-4,4',6,6'-tetraamino-1,1'-bis(4-(methylthio)phenyl)-2,2'-dioxo-1,1',2,2'-tetrahydro-[3,3'-bipyrrolo[2,3-b]pyridinylidene]-5,5'-dicarbonitrile
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References
1. Li K, et al. Sci Adv. 2025 Mar 7;11(10):eadr8146.
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