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Chemical Structure : WEHI-9625
Catalog No.: PC-73094Not For Human Use, Lab Use Only.
WEHI-9625 (WEHI9625) is a small molecule selectively binds to VDAC2 and promotes its ability to inhibits apoptosis (EC50=69 nM) driven by murine BAK, selectively blocks murine BAK-mediated apoptosis.
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WEHI-9625 (WEHI9625) is a small molecule selectively binds to VDAC2 and promotes its ability to inhibits apoptosis (EC50=69 nM) driven by murine BAK, selectively blocks murine BAK-mediated apoptosis.
VDAC2, but not VDAC1 or VDAC3, is essential for WEHI-9625 and its analogs to block BAK-mediated apoptosis.
WEHI-9625 acts by enhancing the VDAC2-BAK interaction.
WEHI-9625 blocks apoptosis before mitochondrial damage, preserving cellular function and long-term clonogenic potential.
| M.Wt | 593.712 | |
| Formula | C34H27NO5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. van Delft MF, et al. Nat Chem Biol. 2019 Nov;15(11):1057-1066.
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