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Chemical Structure : WH-4-023
CAS No.: 837422-57-8
Catalog No.: PC-42962Not For Human Use, Lab Use Only.
WH-4-023 (KIN-112) is a potent and selective dual Lck/Src inhibitor with IC50 of 0.6 nM/1 nM for Lck and Src kinase respectively, displays little to no inhibition on p38α, Btk, KDR (IC50>100 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg (Free Sample) | $18 | In stock | |
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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WH-4-023 (KIN-112) is a potent and selective dual Lck/Src inhibitor with IC50 of 0.6 nM/1 nM for Lck and Src kinase respectively, displays little to no inhibition on p38α, Btk, KDR (IC50>100 nM).
WH-4-023 (KIN-112) inhibits anti-CD3/CD28-induced T cell IL-2 secretion and T cell proliferation with IC50 of 61 nM and 490 nM, respectively.
WH-4-023 (KIN-112) inhibits anti-CD3-induced IL-2 production in in vivo model of T cell activation.
WH-4-023 (KIN-112) also can induce cell death in GC-resistant T-ALL cells.
| M.Wt | 568.666 | |
| Formula | C32H36N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 46.8 mg/mL |
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| Chemical Name/SMILES |
Carbamic acid, N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-, 2,6-dimethylphenyl ester |
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1. Martin MW, et al. J Med Chem. 2006 Aug 10;49(16):4981-91.
2. Serafin V, et al. Blood. 2017 Dec 21;130(25):2750-2761.
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