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WIKI4

Chemical Structure : WIKI4

CAS No.: 838818-26-1

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WIKI4 (WIKI-4)

Catalog No.: PC-45086Not For Human Use, Lab Use Only.

WIKI4 is a novel small molecule inhibitor of the Wnt/β-catenin pathway by inhibiting the enzymatic activity of TNKS2.

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10 mg $98 In stock
25 mg $158 In stock
50 mg $248 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

WIKI4 is a novel small molecule inhibitor of the Wnt/β-catenin pathway by inhibiting the enzymatic activity of TNKS2, prevents auto-ADP-ribosylation of TNKS2 with IC50 of 15 nM.
WIKI4  inhibits expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in cancer cell lines as well as in human embryonic stem cells.

Physicochemical Properties

M.Wt 521.5896
Formula C29H23N5O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 6.8 mg/mL
Chemical Name/SMILES

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[3-[[4-(4-methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-

References

1. James RG, et al. PLoS One. 2012;7(12):e50457.

2. Haikarainen T, et al. PLoS One. 2013 Jun 6;8(6):e65404.

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