WIN 62577 | NK1 receptor antagonist | Probechem Biochemicals

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Chemical Structure : WIN 62577

WIN 62577 (WIN 62,577)

Catalog No.: PC-24029Not For Human Use, Lab Use Only.

WIN 62577 (WIN 62,577) is a selective antagonist of tachykinin NK1 receptor, also is an allosteric enhancer with micromolar potency at muscarinic M3 receptor, also is a highly efficacious inhibitor of main protease (Mpro) of SARS-CoV-2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	437.59
Formula	C29H31N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4S,7S,8R,11S,12R)-8-ethynyl-3,7-dimethyl-18,20,27-triazaheptacyclo[15.11.0.03,15.04,12.07,11.019,27.021,26]octacosa-1(28),15,17,19,21,23,25-heptaen-8-ol

References

1. Briejer MR, et al. Eur J Pharmacol. 1993 Nov 30;250(1):181-3.

2. Lazareno S, et al. J Mol Neurosci. 2003;20(3):363-7.

3. Singh A, et al. Biochemistry. 2025 Jan 30. doi: 10.1021/acs.biochem.4c00535.

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WIN 62577 (WIN 62,577)

Biological Activity

Physicochemical Properties

References

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