Chemical Structure : WIZ degrader 10
CAS No.:
2879251-26-8
WIZ degrader 10
Catalog No.: PC-23413Not For Human Use, Lab Use Only.
WIZ degrader 10 is a potent, and selective molecular glue degrader of the transcription factor WIZ with DC50 of 3 nM and Dmax of 86%.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
WIZ degrader 10 is a potent, and selective molecular glue degrader of the transcription factor WIZ with DC50 of 3 nM and Dmax of 86%.
WIZ degrader 10 induces endogenous WIZ degradation in primary human erythroblasts with DC50 of 2 nM, a maximum depth of 84%, demonstrates a ∼ 9x increase in potency over dWIZ-2.
WIZ degrader 10 increases potency of WIZ degradation translated to an increase in in vitro HbF induction compared with dWIZ-2. WIZ degrader 10 (0.01-1 mg/kg) in duces dose-dependent degradation of WIZ and HbF induction in a humanized NBSGW mouse model.
Physicochemical Properties
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M.Wt
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385.46
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Formula
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C21H27N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(5-(((3R,5R)-1-Ethyl-5-methylpiperidin-3-yl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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References
1. Kerrigan JR, et al. J Med Chem. 2024 Nov 14. doi: 10.1021/acs.jmedchem.4c02251.
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