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Chemical Structure : WIZ degrader 10
Catalog No.: PC-23413Not For Human Use, Lab Use Only.
WIZ degrader 10 is a potent, and selective molecular glue degrader of the transcription factor WIZ with DC50 of 3 nM and Dmax of 86%.
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WIZ degrader 10 is a potent, and selective molecular glue degrader of the transcription factor WIZ with DC50 of 3 nM and Dmax of 86%.
WIZ degrader 10 induces endogenous WIZ degradation in primary human erythroblasts with DC50 of 2 nM, a maximum depth of 84%, demonstrates a ∼ 9x increase in potency over dWIZ-2.
WIZ degrader 10 increases potency of WIZ degradation translated to an increase in in vitro HbF induction compared with dWIZ-2. WIZ degrader 10 (0.01-1 mg/kg) in duces dose-dependent degradation of WIZ and HbF induction in a humanized NBSGW mouse model.
| M.Wt | 385.46 | |
| Formula | C21H27N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kerrigan JR, et al. J Med Chem. 2024 Nov 14. doi: 10.1021/acs.jmedchem.4c02251.
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