WJH-C19

Chemical Structure : WJH-C19

Catalog No.: PC-26020Not For Human Use, Lab Use Only.

WJH-C19 is a novel potent, selective RIPK1 inhibitor with IC50 of 5.7 nM, shows negligible PI3Kα and RIPK2/3.

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Biological Activity

WJH-C19 is a novel potent, selective RIPK1 inhibitor with IC50 of 5.7 nM, shows negligible PI3Kα and RIPK2/3.
WJH-C19 suppressed the RIPK1/RIPK3/MLKL signaling axis, attenuating inflammatory responses.
WJH-C19 achieved robust efficacy in DSS-induced colitis and CFA-induced arthritis models, with favorable pharmacokinetics and no observable toxicity.

Physicochemical Properties

M.Wt	516.02
Formula	C27H22ClN5O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(4-Chlorophenyl)ethyl)-6-(2-(cyclopropanecarboxamido)benzo[d]thiazol-6-yl)imidazo[1,2-a]pyridine-3-carboxamide

References

1. Wu D, et al. bioRxiv [Preprint]. 2025 Dec 16:2025.12.15.694265.

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WJH-C19

Biological Activity

Physicochemical Properties

References

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