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Chemical Structure : WLB-87848
Catalog No.: PC-22349Not For Human Use, Lab Use Only.
WLB-87848 is a highly potent, selective, orally bioavailable sigma-1 receptor (σ1R) agonist with Ki of 9 nM, with ni significant affinity for σ2R.
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WLB-87848 is a highly potent, selective, orally bioavailable sigma-1 receptor (σ1R) agonist with Ki of 9 nM, with ni significant affinity for σ2R.
WLB-87848 displays an agonist profile in the binding immunoglobulin protein/σ1R association assay.
WLB-87848 induces neuron viability in an in vitro model of β-amyloid peptide intoxication, and presents positive results against recognition memory impairment induced by hippocampal injection of Aβ peptide in rats after oral treatment.
| M.Wt | 347.38 | |
| Formula | C17H15F2N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ute Christmann, et al. J Med Chem. 2024 May 16. doi: 10.1021/acs.jmedchem.4c00288.
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