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WLB-87848

Chemical Structure : WLB-87848

CAS No.: 2839205-09-1

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WLB-87848 (WLB87848)

Catalog No.: PC-22349Not For Human Use, Lab Use Only.

WLB-87848 is a highly potent, selective, orally bioavailable sigma-1 receptor (σ1R) agonist with Ki of 9 nM, with ni significant affinity for σ2R.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

WLB-87848 is a highly potent, selective, orally bioavailable sigma-1 receptor (σ1R) agonist with Ki of 9 nM, with ni significant affinity for σ2R.
WLB-87848 displays an agonist profile in the binding immunoglobulin protein/σ1R association assay.
WLB-87848 induces neuron viability in an in vitro model of β-amyloid peptide intoxication, and presents positive results against recognition memory impairment induced by hippocampal injection of Aβ peptide in rats after oral treatment.

Physicochemical Properties

M.Wt 347.38
Formula C17H15F2N3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-3-(1-(3,4-difluorophenyl)ethyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one

References

1. Ute Christmann, et al. J Med Chem. 2024 May 16. doi: 10.1021/acs.jmedchem.4c00288.

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