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Chemical Structure : WLB-89462
Catalog No.: PC-21107Not For Human Use, Lab Use Only.
WLB-89462 (WLB89462) is a potent, highly selective sigma-2 receptor (σ2R) ligand with Ki of 13 nM, >100-fold selective over σ1R (Ki=1777 nM).
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WLB-89462 (WLB89462) is a potent, highly selective sigma-2 receptor (σ2R) ligand with Ki of 13 nM, >100-fold selective over σ1R (Ki=1777 nM).
WLB-89462 shows excellent selectivity in a panel of 180 additional targets (IC50>50 uM), and lack of hERG inhibition.
WLB-89462 (1-10 uM) exerts neuroprotective effect and fully reverses the neurotoxic effect of the MPP+ in the MPP+-induced neurodegeneration in vitro model in rat dopaminergic neurons.
WLB-89462 (10 mg/kg for 10 days) shows neuroprotective activity on short-term memory impairment induced by hippocampal injection of Aβ peptide in rats.
| M.Wt | 399.50 | |
| Formula | C21H29N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ute Christmann, et al. J Med Chem. 2023 Aug 22. doi: 10.1021/acs.jmedchem.3c01060.
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