Chemical Structure : WLB-89462
CAS No.:
2849471-75-4
WLB-89462
(WLB89462)
Catalog No.: PC-21107Not For Human Use, Lab Use Only.
WLB-89462 (WLB89462) is a potent, highly selective sigma-2 receptor (σ2R) ligand with Ki of 13 nM, >100-fold selective over σ1R (Ki=1777 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
WLB-89462 (WLB89462) is a potent, highly selective sigma-2 receptor (σ2R) ligand with Ki of 13 nM, >100-fold selective over σ1R (Ki=1777 nM).
WLB-89462 shows excellent selectivity in a panel of 180 additional targets (IC50>50 uM), and lack of hERG inhibition.
WLB-89462 (1-10 uM) exerts neuroprotective effect and fully reverses the neurotoxic effect of the MPP+ in the MPP+-induced neurodegeneration in vitro model in rat dopaminergic neurons.
WLB-89462 (10 mg/kg for 10 days) shows neuroprotective activity on short-term memory impairment induced by hippocampal injection of Aβ peptide in rats.
Physicochemical Properties
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M.Wt
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399.50
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Formula
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C21H29N5O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(4-(2-Ethyl-5-(3-methylisoxazol-5-yl)pyrimidin-4-yl)piperidin-1-yl)-1-morpholinoethan-1-one
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References
1. Ute Christmann, et al. J Med Chem. 2023 Aug 22. doi: 10.1021/acs.jmedchem.3c01060.
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