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Chemical Structure : WMS-1410
Catalog No.: PC-38728Not For Human Use, Lab Use Only.
WMS-1410 is a NR2B selective NMDA receptor antagonist with Ki value of 14 nM, antagonizes glutamate induced excitotoxicity with IC50 of 18.4 nM.
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WMS-1410 is a NR2B selective NMDA receptor antagonist with Ki value of 14 nM, antagonizes glutamate induced excitotoxicity with IC50 of 18.4 nM.
WMS-1410 displays excellent selectivity over more than 100 further relevant target proteins.
WMS-1410 (100 mg/kg) shows dose dependent analgesic activity in the late neuropathic pain phase of the formalin assay in mice.
| M.Wt | 311.425 | |
| Formula | C20H25NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tewes B, et al. Bioorg Med Chem. 2010 Nov 15;18(22):8005-15.
2. Gresch A, et al. J Pharmacol Exp Ther. 2021 Nov;379(3):235-244.
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