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WMS-1410

Chemical Structure : WMS-1410

CAS No.: 1253197-38-4

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WMS-1410 (WMS1410)

Catalog No.: PC-38728Not For Human Use, Lab Use Only.

WMS-1410 is a NR2B selective NMDA receptor antagonist with Ki value of 14 nM, antagonizes glutamate induced excitotoxicity with IC50 of 18.4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    WMS-1410 is a NR2B selective NMDA receptor antagonist with Ki value of 14 nM, antagonizes glutamate induced excitotoxicity with IC50 of 18.4 nM.
    WMS-1410 displays excellent selectivity over more than 100 further relevant target proteins.
    WMS-1410 (100 mg/kg) shows dose dependent analgesic activity in the late neuropathic pain phase of the formalin assay in mice.

    Physicochemical Properties

    M.Wt 311.425
    Formula C20H25NO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(4-Phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

    References

    1. Tewes B, et al. Bioorg Med Chem. 2010 Nov 15;18(22):8005-15.

    2. Gresch A, et al. J Pharmacol Exp Ther. 2021 Nov;379(3):235-244.

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