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WP760

Chemical Structure : WP760

CAS No.:

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WP760 (WP 760;WP-760)

Catalog No.: PC-61008Not For Human Use, Lab Use Only.

A bis-anthracycline and melanoma selective agent that demonstrates anti-melanoma activity at low nanomolar concentrations.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

WP760 is a bis-anthracycline and melanoma selective agent that demonstrates anti-melanoma activity at low nanomolar concentrations.
WP760 abrogates melanoma cell growth by transcription inhibition, p53 activation and IGF1R downregulation; inhibits melanoma cell proliferation (IC50 =1-99 nM), impaired clonogenic cell survival (100 nM), and inhibits spheroid growth (>300 nM), but does not induce double-stranded DNA breaks.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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