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Chemical Structure : WRW4
CAS No.: 878557-55-2
Catalog No.: PC-20391Not For Human Use, Lab Use Only.
WRW4 (Trp-Arg-Trp-Trp-Trp-Trp) is a selective antagonist of formyl peptide receptor 2 (FPR2, FPRL1) signaling, inhibits WKYMVm binding to FPR2 with IC50 of 0.23 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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WRW4 (Trp-Arg-Trp-Trp-Trp-Trp) is a selective antagonist of formyl peptide receptor 2 (FPR2, FPRL1) signaling, inhibits WKYMVm binding to FPR2 with IC50 of 0.23 uM.
WRW4 inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide.
WRW4 also inhibits FPR2-mediated signaling in human neutrophils.
WRW4 blocks chemotactic migration and superoxide generation by amyloid β42 peptide.
| M.Wt | 1104.27 | |
| Formula | C61H65N15O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
L-Tryptophyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-tryptophyl-L-tryptophanamide |
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1. Bae YS, et al. J Immunol. 2004 Jul 1;173(1):607-14.
2. Karlsson J, et al. Biochem Pharmacol. 2006 May 14;71(10):1488-96.
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