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Chemical Structure : WT-161
CAS No.: 1206731-57-8
Catalog No.: PC-70299Not For Human Use, Lab Use Only.
WT-161 (WT161) is a potent, selective, and bioavailable HDAC6 inhibitor with IC50 0.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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WT-161 (WT161) is a potent, selective, and bioavailable HDAC6 inhibitor with IC50 0.4 nM.
WT-161 displays >20-fold selectivity over HDAC1/2/3/8.
WT-161 selectively inhibits HDAC6 and dramatically increases levels of acetylated α-tubulin with little effect on global lysine acetylation in cells.
WT-161 reversibly and rapidly induces the accumulation of Ac-α-tubulin in MM cell lines, displays synergism with both BTZ and CFZ, caspase activation and apoptosis.
WT-161 demonstrates a significant antitumor effect in human MM cell xenograft mouse model combined with BTZ.
| M.Wt | 458.55 | |
| Formula | C27H30N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Octanoic acid, 8-(hydroxyamino)-8-oxo-, 2-[[4-(diphenylamino)phenyl]methylene]hydrazide |
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1. Hideshima T, et al. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13162-13167.
2. Hideshima T, et al. Oncotarget. 2017 Jul 5. doi: 10.18632/oncotarget.19019.
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