WX-02-23

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Chemical Structure : WX-02-23

Catalog No.: PC-22145Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

WX-02-23 is a covalent small molecule ligand of transcription factor FOXA1 with EC50 of 2 uM in NanoBRET assay, binds cysteine (C258) and promotes the stereoselective and site-specific binding of FOXA1 to DNA.
WX-02-23 stereoselectively blocks CJR-6A reactivity with purified MBP-FOXA1-FKHD protein in the presence of oligonucleotide with IC50 of 8 uM.
WX-02-23 causes the rapid redistribution of FOXA1 across chromatin.

Physicochemical Properties

M.Wt	459.50
Formula	C26H25N3O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((1R,3S)-1-(benzo[d][1,3]dioxol-5-yl)-3-(morpholine-4-carbonyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)prop-2-en-1-one

References

1. Won SJ, et al. bioRxiv. 2024 Mar 21:2024.03.21.586158.

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WX-02-23

Biological Activity

Physicochemical Properties

References

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