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WX-UK1

Chemical Structure : WX-UK1

CAS No.: 220355-63-5

WX-UK1 (UKI-1)

Catalog No.: PC-42144Not For Human Use, Lab Use Only.

WX-UK1 (UKI-1) is a small synthetic serine protease uPA (urokinase-type plasminogen activator) inhibitor that blocks tumor cell invasion, metastasis and primary tumor growth.

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5 mg $248 In stock
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Biological Activity

WX-UK1 (UKI-1) is a small synthetic serine protease uPA (urokinase-type plasminogen activator) inhibitor that blocks tumor cell invasion, metastasis and primary tumor growth.
WX-UK1 selectively inhibits tumour-related proteases from rats and humans such as uPA, plasmin, or thrombin in the sub or low micromolar range.
WX-UK1 impaired primary tumour growth and metastasis of BN472 rat breast cancer.

Physicochemical Properties

M.Wt 613.8111
Formula C32H47N5O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 28 mg/mL

Chemical Name/SMILES

1-Piperazinecarboxylic acid, 4-[(2S)-3-[3-(aminoiminomethyl)phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-, ethyl ester

References

1. Ertongur S, et al. Int J Cancer. 2004 Jul 20;110(6):815-24.

2. Schuh T, et al. Biol Chem. 2003 Feb;384(2):311-5.

3. Setyono-Han B, et al. Thromb Haemost. 2005 Apr;93(4):779-86.

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